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    usp42 ubiquitin specific peptidase 42 [ Danio rerio (zebrafish) ]

    Gene ID: 327528, updated on 11-Apr-2024

    Summary

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    Official Symbol
    usp42provided by ZNC
    Official Full Name
    ubiquitin specific peptidase 42provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-5739
    See related
    Ensembl:ENSDARG00000077300 AllianceGenome:ZFIN:ZDB-GENE-030131-5739
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fi15g04; wu:fi15g04
    Summary
    Predicted to enable cysteine-type endopeptidase activity and thiol-dependent deubiquitinase. Predicted to be involved in protein deubiquitination and regulation of apoptotic process. Predicted to act upstream of or within ubiquitin-dependent protein catabolic process. Predicted to be active in cytosol and nucleus. Orthologous to human USP42 (ubiquitin specific peptidase 42). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    Location:
    chromosome: 12
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (17570115..17592305, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (17448241..17470336, complement)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene multiple inositol-polyphosphate phosphatase 1b Neighboring gene cytohesin 3a Neighboring gene eukaryotic translation initiation factor 2-alpha kinase 1 Neighboring gene PMS1 homolog 2, mismatch repair system component Neighboring gene radial spoke head 10 homolog B Neighboring gene discs, large (Drosophila) homolog-associated protein 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Natural mixtures of POPs affected body weight gain and induced transcription of genes involved in weight regulation and insulin signaling. Lyche JL, et al. Aquat Toxicol, 2011 Apr. PMID 21356182
    2. Natural mixtures of persistent organic pollutants (POP) increase weight gain, advance puberty, and induce changes in gene expression associated with steroid hormones and obesity in female zebrafish. Lyche JL, et al. J Toxicol Environ Health A, 2010. PMID 20526952
    3. A shifted repertoire of endocannabinoid genes in the zebrafish (Danio rerio). McPartland JM, et al. Mol Genet Genomics, 2007 May. PMID 17256142
    4. Evolution after Whole-Genome Duplication: Teleost MicroRNAs. Desvignes T, et al. Mol Biol Evol, 2021 Jul 29. PMID 33871629, Free PMC Article
    5. Genome-wide loss-of-function analysis of deubiquitylating enzymes for zebrafish development. Tse WK, et al. BMC Genomics, 2009 Dec 30. PMID 20040115, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1453

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 42
    XP_005169520.1
    XP_017214003.1
    XP_021328186.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      17570115..17592305 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005169463.3 → XP_005169520.1  ubiquitin carboxyl-terminal hydrolase 42 isoform X1

      UniProtKB/TrEMBL
      A0A0R4IA55, A0A8M2BGS6, F1QY38
      Related
      ENSDARP00000117687.2, ENSDART00000134597.4
      Conserved Domains (4) summary
      cd02661
      Location:113 → 412
      Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam00443
      Location:114 → 411
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam08648
      Location:860 → 968
      DUF1777; Protein of unknown function (DUF1777)
      pfam12871
      Location:861 → 933
      PRP38_assoc; Pre-mRNA-splicing factor 38-associated hydrophilic C-term

    2. XM_017358514.2 → XP_017214003.1  ubiquitin carboxyl-terminal hydrolase 42 isoform X2

      UniProtKB/TrEMBL
      A0A8M9Q0M3
      Conserved Domains (2) summary
      cd02661
      Location:33 → 332
      Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam08648
      Location:780 → 887
      DUF1777; Protein of unknown function (DUF1777)

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394834.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      15977..32879 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021472511.1 → XP_021328186.1  ubiquitin carboxyl-terminal hydrolase 42 isoform X2

      UniProtKB/TrEMBL
      A0A8M9Q0M3
      Conserved Domains (2) summary
      cd02661
      Location:33 → 332
      Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam08648
      Location:780 → 887
      DUF1777; Protein of unknown function (DUF1777)
    Nucleotide Protein Strain
    Heading Accession and Version

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